This course will provide an understanding of the ethical guidelines, issues and challenges of conducting research on human subjects. Special rights and concerns of participants will be explored. Students will learn to cope with conflicts of interest and will discuss challenging case scenarios such as genetic testing, limits of confidentiality and the meaning of minimal risk. Health care legislation, guidelines, regulatory and research contractual issues will be covered in the context of protecting all research parties and explaining their rights and liabilities. The format will be a series of lectures and small groups using a problem-based approach to learning.