Cannabis is a psychoactive drug that is established to have a variety of risks and harms. This course will review the strength of evidence behind the different risks associated. Priority topics are impairment leading to accidents; cannabis misuse/cannabis use disorder; associations with anxiety, depression, and schizophrenia; effects of cannabis on cognition and brain development; and adverse consequences for lung health. Finally, the course will review guidelines for reducing risk when consuming cannabis and evidence-based practices in the treatment of cannabis use disorder.